Differences in Pharmacokinetics of Amphotericin B Lipid Formulations Despite Clinical Equivalence
نویسندگان
چکیده
منابع مشابه
Compartmentalized intrapulmonary pharmacokinetics of amphotericin B and its lipid formulations.
We investigated the compartmentalized intrapulmonary pharmacokinetics of amphotericin B and its lipid formulations in healthy rabbits. Cohorts of three to seven noninfected, catheterized rabbits received 1 mg of amphotericin B deoxycholate (DAMB) per kg of body weight or 5 mg of either amphotericin B colloidal dispersion (ABCD), amphotericin B lipid complex (ABLC), or liposomal amphotericin B (...
متن کاملLipid amphotericin B formulations as comparators in clinical trials.
cidences of toxicity, it is doubtful that the entire sum would be recouped. On the contrary, Cagnoni et al. [8] estimated that the use of LFABs in a randomized study added approximately $5800 to the average cost of hospitalization. This cost likely underestimates the true financial burden in typical clinical practice, as the doses of LFABs utilized in the study were modest (most patients receiv...
متن کاملComparative toxicities and pharmacokinetics of intrathecal lipid (amphotericin B colloidal dispersion) and conventional deoxycholate formulations of amphotericin B in rabbits.
The lipid formulation of amphotericin B, Amphotec (ABCD), has not been used intrathecally. After a single intrathecal dose or after four doses, conventionally formulated deoxycholate amphotericin B (AMB) (Fungizone) resulted in higher levels of amphotericin B in the cerebrospinal fluid of rabbits than did ABCD. Clinically and histologically, ABCD was about threefold less toxic than AMB after a ...
متن کاملDose-dependent pharmacokinetics of amphotericin B lipid complex in rabbits.
Amphotericin B lipid complex (ABLC) was recently approved by the Food and Drug Administration for treatment of patients with invasive fungal infections who are intolerant of or refractory to conventional amphotericin B therapy. Little is known, however, about the pharmacokinetics of this new antifungal compound. We therefore investigated the pharmacokinetics of ABLC in comparison with those of ...
متن کاملPenetration of amphotericin B lipid formulations into pleural effusion.
The penetration of the amphotericin B (AMB) lipid formulations (liposomal AMB, AMB colloidal dispersion, and AMB lipid complex formulations) into pleural effusions in seven critically ill patients was assessed. AMB was detected in all pleural effusion samples at concentrations ranging from 0.02 to 0.43 microg/ml. The penetration ratio was 3 to 44%.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 2003
ISSN: 1537-6591,1058-4838
DOI: 10.1086/374876